Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids
in cells. PUFAs regulate cellular function through the formation of derived lipid mediators …

INTRODUCTION Obesity accounts for a substantial and growing burden of disease globally.
Body adiposity is highly heritable, and human genetic studies can lead to biological and …

The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …

Rationale: High-salt diet is one of the most important risk factors for hypertension. Intestinal
flora has been reported to be associated with high salt–induced hypertension (hSIH) …

Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy
and validated pharmacological targets. Here, using integrative'omics' analysis, we identified …

Immune checkpoint blockade (ICB) is a promising treatment strategy for colorectal cancer
(CRC) patients. However, most CRC patients do not response well to ICB therapy …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …