Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure

M Van Bodegom, JR Homberg… - Frontiers in cellular …, 2017 - frontiersin.org
Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Cognitive reserve and the prevention of dementia: the role of physical and cognitive activities

ST Cheng - Current psychiatry reports, 2016 - Springer
Abstract Purpose of Review The article discusses the two most significant modifiable risk
factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and …

Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior

YD Li, YJ Luo, ZK Chen, L Quintanilla, Y Cherasse… - Nature …, 2022 - nature.com
Adult hippocampal neurogenesis plays a critical role in memory and emotion processing,
and this process is dynamically regulated by neural circuit activity. However, it remains …

Distinct contribution of adult-born hippocampal granule cells to context encoding

NB Danielson, P Kaifosh, JD Zaremba, M Lovett-Barron… - Neuron, 2016 - cell.com
Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it
remains unknown how these cells behave in vivo. Here, we have used two-photon calcium …

The corticohippocampal circuit, synaptic plasticity, and memory

J Basu, SA Siegelbaum - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Synaptic plasticity serves as a cellular substrate for information storage in the central
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …

Adult hippocampal neurogenesis, fear generalization, and stress

A Besnard, A Sahay - Neuropsychopharmacology, 2016 - nature.com
The generalization of fear is an adaptive, behavioral, and physiological response to the
likelihood of threat in the environment. In contrast, the overgeneralization of fear, a cardinal …

Neurogenesis in the adult hippocampus: history, regulation, and prospective roles

J Fares, Z Bou Diab, S Nabha… - International Journal of …, 2019 - Taylor & Francis
Background: The hippocampus is one of the sites in the mammalian brain that is capable of
continuously generating controversy. Adult neurogenesis is a remarkable process, and yet …

[HTML][HTML] Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells

SG Temprana, LA Mongiat, SM Yang, MF Trinchero… - Neuron, 2015 - cell.com
Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of
enhanced activity and synaptic plasticity before becoming mature. The impact of developing …

Activation of local inhibitory circuits in the dentate gyrus by adult‐born neurons

LJ Drew, MA Kheirbek, VM Luna, CA Denny… - …, 2016 - Wiley Online Library
Robust incorporation of new principal cells into pre‐existing circuitry in the adult mammalian
brain is unique to the hippocampal dentate gyrus (DG). We asked if adult‐born granule cells …

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

N Forte, S Boccella, L Tunisi… - Nature …, 2021 - nature.com
The mammalian brain stores and distinguishes among episodic memories, ie memories
formed during the personal experience, through a mechanism of pattern separation …