Exosomes, a new star for targeted delivery

H Chen, L Wang, X Zeng, H Schwarz… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are cell-secreted nanoparticles (generally with a size of 30–150 nm) bearing
numerous biological molecules including nucleic acids, proteins and lipids, which are …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders

M Riazifar, MR Mohammadi, EJ Pone, A Yeri… - ACS …, 2019 - ACS Publications
To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

Extracellular vesicles round off communication in the nervous system

V Budnik, C Ruiz-Cañada, F Wendler - Nature Reviews Neuroscience, 2016 - nature.com
Functional neural competence and integrity require interactive exchanges among sensory
and motor neurons, interneurons and glial cells. Recent studies have attributed some of the …

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

D Rufino-Ramos, PR Albuquerque, V Carmona… - Journal of Controlled …, 2017 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all
cells, including brain cells. EVs are a major term that includes apoptotic bodies …

Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation

D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …

Molecular control of oligodendrocyte development

B Elbaz, B Popko - Trends in neurosciences, 2019 - cell.com
Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …