[HTML][HTML] Repurpose dasatinib and quercetin: targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration

Y Wang, L Che, X Chen, Z He, D Song, Y Yuan, C Liu - Bioactive Materials, 2023 - Elsevier
Clinical therapies developed for estrogen-deficiency-driven postmenopausal osteoporosis
(PMO) and related diseases, such as bone degeneration, show multiple adverse effects …

Effect of sequential treatments with alendronate, parathyroid hormone (1–34) and raloxifene on cortical bone mass and strength in ovariectomized rats

SK Amugongo, W Yao, J Jia, W Dai, YAE Lay, L Jiang… - Bone, 2014 - Elsevier
Anti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis
continuously or sequentially for many years. However their impact on cortical bone quality …

Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model

W Geng, X Yan, H Du, J Cui, L Li, F Chen - Biochemical and Biophysical …, 2013 - Elsevier
Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally.
Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is …

Formononetin reverses established osteopenia in adult ovariectomized rats

AM Tyagi, K Srivastava, AK Singh, A Kumar… - Menopause, 2012 - journals.lww.com
Objective Formononetin (Formo) prevents ovariectomy (Ovx)-induced bone loss in rats.
However, there are no reports on the curative effects of Formo. The objective of this study …

Evaluation of bone turnover after bisphosphonate withdrawal and its influence on implant osseointegration: an in vivo study in rats

F Frizzera, MHA Verzola, RS de Molon… - Clinical oral …, 2019 - Springer
Objectives The aim of this study was to investigate bone turnover alterations after
alendronate (ALD) withdrawal and its influence on dental implants osseointegration …

Anomalous bone changes in ovariectomized type 2 diabetic rats: inappropriately low bone turnover with bone loss in an estrogen-deficient condition

R Aeimlapa, K Wongdee… - American Journal …, 2019 - journals.physiology.org
Estrogen deprivation accelerates bone resorption, leading to imbalance of bone remodeling
and osteoporosis in postmenopausal women. In the elderly, type 2 diabetes mellitus (T2DM) …

Bisphosphonate withdrawal: effects on bone formation and bone resorption in maturing male mice

FC Ko, L Karim, DJ Brooks, ML Bouxsein… - Journal of Bone and …, 2017 - academic.oup.com
Bisphosphonates are being increasingly used to treat pediatric patients with skeletal
disorders. However, the effects of long‐term bisphosphonate therapy and cessation of …

Treatment with Rhizoma Dioscoreae Extract Has Protective Effect on Osteopenia in Ovariectomized Rats

Z Zhang, L Xiang, D Bai, X Fu, W Wang… - The Scientific World …, 2014 - Wiley Online Library
The aims of this study were to evaluate the osteoprotective effect of aqueous extract from
Rhizoma Dioscoreae (RDE) on rats with ovariectomy‐(OVX‐) induced osteopenia. Our …

Combined treatment with a traditional Chinese medicine, Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) and alendronate improves bone microstructure in ovariectomized …

H Chen, M Wu, K Kubo - Journal of Ethnopharmacology, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Hachimi-jio-gan is one of the most common
recipes in traditional Chinese, Japanese and Korean medicines and has been used for …

[HTML][HTML] Bone loss prevention in ovariectomized rats using stable amorphous calcium carbonate

G Shaltiel, E Bar-David, OE Meiron, E Waltman… - 2013 - scirp.org
In assessing the relationship between calcium supplementation and maintaining bone mass
or reducing the risk of fracture, the effectiveness of calcium supplementation has never been …