The separation and detection of isomers remains a challenge for many areas of mass
spectrometry. This article highlights laser photodissociation and ion mobility strategies that …

There is increasing biopharmaceutical interest in oligosaccharides and glycosylation. A key
requirement for these sample types is the ability to characterize the chain length, branching …

The vast array of molecular isomerisms which form the complex molecular structure of
carbohydrates is the foundation of their biological versatility but defies the analytical chemist …

Lipids are small but complex biomolecules that feature an immense structural and functional
diversity. The molecular structure and biological functions of lipids are intricately linked …

Understanding and controlling peptide aggregation are critical due to its neurotoxic
implications. However, structural information about the key intermediates, the oligomers, is …

One of the main challenges of analyzing intact proteins on an ion trap mass spectrometer is
the mass range limitation, especially for miniature mass spectrometers. In this study, a high …

Ion mobility mass spectrometry (IM-MS) has proven to be an excellent method to
characterize the structure of amyloidogenic protein and peptide aggregates, which are …

Infrared and electronic spectra are indispensable for understanding the structural and
energetic properties of charged molecules and clusters in the gas phase. However, the …

The influence of oriented electric fields on chemical reactivity and photochemistry is an area
of increasing interest. Within a molecule, different protonation sites offer the opportunity to …

Measuring the conformations and effective charges of proteins in solution is critical for
investigating protein bioactivity, but their rapid analysis remains a challenging problem …