Tendinopathy

NL Millar, KG Silbernagel, K Thorborg… - Nature reviews Disease …, 2021 - nature.com
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

Inflammatory mechanisms in tendinopathy–towards translation

NL Millar, GAC Murrell, IB McInnes - Nature reviews rheumatology, 2017 - nature.com
Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

Tendon basic science: Development, repair, regeneration, and healing

N Andarawis‐Puri, EL Flatow… - Journal of Orthopaedic …, 2015 - Wiley Online Library
Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions.
Despite the prevalence of these injuries, a limited number of investigators are conducting …

Spectrum of tendon pathologies: Triggers, trails and end-state

S Steinmann, CG Pfeifer, C Brochhausen… - International journal of …, 2020 - mdpi.com
The biggest compartment of the musculoskeletal system is the tendons and ligaments. In
particular, tendons are dense tissues connecting muscle to bone that are critical for the …

Obesity as a risk factor for tendinopathy: a systematic review

F Franceschi, R Papalia, M Paciotti… - International journal …, 2014 - Wiley Online Library
Purpose. In the last few years, evidence has emerged to support the possible association
between increased BMI and susceptibility to some musculoskeletal diseases. We …

Tendon healing is adversely affected by low-grade inflammation

E Chisari, L Rehak, WS Khan, N Maffulli - Journal of Orthopaedic Surgery …, 2021 - Springer
Background Tendinopathy is common, presents with pain and activity limitation, and is
associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a …

[HTML][HTML] Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity

T Ye, Z Chen, J Zhang, L Luo, R Gao, L Gong, Y Du… - Bioactive Materials, 2023 - Elsevier
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and
reduced performance. The therapeutic effect of stem cell derived-small extracellular vesicles …

In vivo biological response to extracorporeal shockwave therapy in human tendinopathy: Response of tendinopathy to shockwave therapy

C Waugh, D Morrissey, E Jones, G Riley… - European Cells and …, 2015 - ueaeprints.uea.ac.uk
Extracorporeal shock wave therapy (ESWT) is a non-invasive treatment for chronic
tendinopathies, however little is known about the in-vivo biological mechanisms of ESWT …

The functions and mechanisms of basic fibroblast growth factor in tendon repair

J Lu, L Jiang, Y Chen, K Lyu, B Zhu, Y Li, X Liu… - Frontiers in …, 2022 - frontiersin.org
Tendon injury is a disorder of the musculoskeletal system caused by overuse or trauma,
which is characterized by pain and limitations in joint function. Since tendon healing is …

Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise

EM Spiesz, CT Thorpe, S Chaudhry… - Journal of …, 2015 - Wiley Online Library
The role of inflammation in tendon injury is uncertain and a topic of current interest. In vitro
studies of tendon accelerated overload damage can serve as a valuable source of …