Glycosyltransferases: mechanisms and applications in natural product development

DM Liang, JH Liu, H Wu, BB Wang, HJ Zhu… - Chemical Society …, 2015 - pubs.rsc.org
Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Human milk oligosaccharides (HMOS): structure, function, and enzyme-catalyzed synthesis

X Chen - Advances in carbohydrate chemistry and biochemistry, 2015 - Elsevier
The important roles played by human milk oligosaccharides (HMOS), the third major
component of human milk, in the health of breast-fed infants have been increasingly …

Leloir glycosyltransferases as biocatalysts for chemical production

B Nidetzky, A Gutmann, C Zhong - ACS Catalysis, 2018 - ACS Publications
Glycosylation is a chemical transformation that is centrally important in all glycoscience and
related technologies. Catalysts offering good control over reactivity and selectivity in …

Enzymatic and cell factory approaches to the production of human milk oligosaccharides

M Faijes, M Castejón-Vilatersana, C Val-Cid… - Biotechnology …, 2019 - Elsevier
Infant formula milk companies try to develop fortified formula milk that mimics human milk as
closely as possible, since it is well-known that breast milk has considerable implications in …

Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose

Y Zhu, J Zhang, W Zhang, W Mu - Biotechnology Advances, 2023 - Elsevier
Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations

GA Sprenger, F Baumgärtner, C Albermann - Journal of biotechnology, 2017 - Elsevier
Human milk oligosaccharides (HMO) are almost unique constituents of breast milk and are
not found in appreciable amounts in cow milk. Due to several positive aspects of HMO for …

[HTML][HTML] Leloir glycosyltransferases in applied biocatalysis: A multidisciplinary approach

L Mestrom, M Przypis, D Kowalczykiewicz… - International journal of …, 2019 - mdpi.com
Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …

Enabling chemoenzymatic strategies and enzymes for synthesizing sialyl glycans and sialyl glycoconjugates

X Chen - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Sialic acids are fascinating negatively charged nine-carbon monosaccharides.
Sialic acid-containing glycans and glycoconjugates are structurally diverse, functionally …

One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates

H Yu, X Chen - Organic & biomolecular chemistry, 2016 - pubs.rsc.org
Glycosyltransferase-catalyzed enzymatic and chemoenzymatic syntheses are powerful
approaches for the production of oligosaccharides, polysaccharides, glycoconjugates, and …

Biosynthesis of human milk oligosaccharides: enzyme cascade and metabolic engineering approaches

J Meng, Y Zhu, H Wang, H Cao… - Journal of Agricultural and …, 2023 - ACS Publications
Human milk oligosaccharides (HMOs) have unique beneficial effects for infants and are
considered as the new gold standard for premium infant formula. They are a collection of …