Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

The intestinal barrier and current techniques for the assessment of gut permeability

I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity

Y Kinashi, K Hase - Frontiers in immunology, 2021 - frontiersin.org
The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

C Stolfi, C Maresca, G Monteleone, F Laudisi - Biomedicines, 2022 - mdpi.com
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

[HTML][HTML] All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

A Fasano - F1000Research, 2020 - ncbi.nlm.nih.gov
Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

Celiac disease: a comprehensive current review

G Caio, U Volta, A Sapone, DA Leffler, R De Giorgio… - BMC medicine, 2019 - Springer
Background Celiac disease remains a challenging condition because of a steady increase
in knowledge tackling its pathophysiology, diagnosis, management, and possible …

[HTML][HTML] Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

J Mouries, P Brescia, A Silvestri, I Spadoni… - Journal of …, 2019 - Elsevier
Background & Aims Fatty liver disease, including non-alcoholic fatty liver (NAFLD) and
steatohepatitis (NASH), has been associated with increased intestinal barrier permeability …

The intestinal barrier: a fundamental role in health and disease

M Vancamelbeke, S Vermeire - Expert review of gastroenterology …, 2017 - Taylor & Francis
Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

The intestinal epithelial barrier: a therapeutic target?

MA Odenwald, JR Turner - Nature reviews Gastroenterology & …, 2017 - nature.com
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

The role of intestinal mucosal barrier in autoimmune disease: A potential target

J An, Y Liu, Y Wang, R Fan, X Hu, F Zhang… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a series of diseases involving multiple tissues and organs,
characterized by the over production of abnormal multiple antibodies. Although most studies …