Budding yeast, like other eukaryotes, carries its genetic information on chromosomes that
are sequestered from other cellular constituents by a double membrane, which forms the …

In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication
named origins are dispersed across each of the linear chromosomes. During S-phase, only …

The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities.
DDK, in particular, is involved in setting the temporal program of origin activation, a …

Complete genome duplication is essential for genetic homeostasis over successive cell
generations. Higher eukaryotes possess a complex genome replication program that …

Complete duplication of large metazoan chromosomes requires thousands of potential
initiation sites, only a small fraction of which are selected in each cell cycle. Assembly of the …

Successful duplication of the genome requires the accurate replication of billions of base
pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome …

The differential replication timing of eukaryotic replication origins has long been linked with
epigenetic regulation of gene expression and more recently with genome stability and …

Origins of DNA replication on eukaryotic genomes have been observed to fire during S
phase in a coordinated manner. Studies in yeast indicate that origin firing is affected by …

Replication timing (RT) domains are stable units of chromosome structure that are regulated
in the context of development and disease. Conventional genome-wide RT mapping …

The DNA replication program is, in part, determined by the epigenetic landscape that
governs local chromosome architecture and directs chromosome duplication. Replication …