Aluminum-containing adjuvants are widely used in preventive vaccines against infectious
diseases and in preparations for allergy immunotherapy. The mechanism by which they …

Cancer and the immune system are intimately related. Much of the bulk of tumors is
comprised of stromal leukocytes with immune functions, which serve to both promote and …

T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the
mechanisms underlying variable immune responses between individuals are not well …

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface
expression, is used by many viruses to evade immune recognition. In particular …

Dendritic cells (DCs) are highly effective antigen-presenting cells that shape immune
responses. Vaccines that deliver antigen to the DCs can harness their power. DC surface …

Pacific white shrimp (Litopenaeus vannamei) is the most extensively farmed crustacean
species in the world. White spot syndrome virus (WSSV) is one of the major pathogens in the …

Despite recent clinical advances in immunotherapy, a fraction of cancer patients fails to
respond to these interventions. Evidence from preclinical mouse models as well as clinical …

Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent
severe COVID-19 disease by at least three distinct mechanisms:(1) as immunostimulants …

Effective viral clearance requires the induction of virus-specific CD8+ cytotoxic T
lymphocytes (CTL). Since dendritic cells (DC) have a central role in initiating and shaping …

Several foreign antigens such as those derived from viruses and bacteria have been linked
to long-term deleterious effects on the brain and other organs; yet, health outcomes …