ABSTRACT Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that
drives the movement of diverse cargos along the microtubule cytoskeleton, including …

Highlights•Lysosomes degrade diverse cargos that are captured within endosomes and
autophagosomes.•Lysosome abundance in axons is limited by efficient retrograde transport …

The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons
of vertebrates and invertebrates. How JIP3's interaction with dynein and kinesin-1 …

Lysosomes robustly accumulate within axonal swellings at Alzheimer's disease (AD)
amyloid plaques. However, the underlying mechanisms and disease relevance of such …

How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …

Lysosomes support diverse cellular functions by acting as sites of macromolecule
degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by …

Autophagy is a key cellular degradative pathway, important for neuronal homeostasis and
function. Disruption of autophagy is associated with neuronal dysfunction and …

The axon initial segment is a highly specialized neuronal compartment, identified almost 50
years ago by the pioneers of electron microscopy. Located in the first 50 μm of the axon, it …

Axons of the mammalian CNS lose the ability to regenerate soon after development due to
both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for …

The transmission of information in the brain depends on the highly polarized architecture of
neurons. A number of cellular transport processes support this organization, including active …