Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical
fields are interconnected and synergized. A way to depict that innovation is by conducting a …

Oxidation is one of the most important processes used by the chemical industry. However,
many of the methods that are used pose significant sustainability and environmental issues …

The asymmetric reductive amination of ketones enables the one-step synthesis of chiral
amines from readily available starting materials. Here we report the discovery of a family of …

Production of platform chemicals from renewable feedstocks is becoming increasingly
important due to concerns on environmental contamination, climate change, and depletion …

Chiral amines are essential building blocks to manufacture a plethora of valuable
compounds, including active pharmaceutical ingredients (API). It is estimated that about half …

The non-natural needs of industrial applications often require new or improved enzymes.
The structures and properties of enzymes are difficult to predict or design de novo. Instead …

Herein, we report a one-pot, chemoenzymatic process for the synthesis of enantioenriched
C (1)-allylated tetrahydroisoquinolines. This transformation couples a monoamine oxidase …