Dysregulation of peptide-activated pathways causes a range of diseases, fostering the
discovery and clinical development of peptide drugs. Many endogenous peptides activate G …

Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV)
function and survival than men; however, the underlying mechanisms are unknown. We …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Apelin is a vasoactive peptide and is an endogenous ligand for APJ receptors, which are
widely expressed in blood vessels, heart, and cardiovascular regulatory regions of the brain …

Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-
coupled receptor family. Apelin and APJ are widely distributed in the body and play potential …

Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-
associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular …

Doxorubicin (DOX) is a widely used and effective antineoplastic drug; however, its clinical
application is limited by cardiotoxicity. A safe and effective strategy to prevent from …

Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic
option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein …