Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

The imbalance between energy intake and expenditure is the main cause of excessive
overweight and obesity. Technically, obesity is defined as the abnormal accumulation of≥ …

This WHO classification covers tumors of soft tissue and bone including inherited tumor
syndromes. Each entity is extensively discussed with information on clinicopathological …

BACKGROUND Histologic grade is said to be the most important prognostic factor in adult
soft tissue sarcomas (STS), but most grading systems have been tested in the overall …

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial
differentiation, with a propensity to occur in young adults and which can arise at almost any …

Significant progress has been made in understanding the molecular genetic alterations
involved in sarcomagenesis. Cytogenetic and molecular studies have identified nonrandom …

Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of
epithelial differentiation. They consistently show a specific t (X; 18; p11; q11), which usually …

Bone is a highly specialized connective tissue, its properties depending largely on the
unique nature of its extracellular matrix. In addition to providing mechanical support and …

BACKGROUND The optimal treatment strategy for synovial sarcoma (SS) is subject to
debate, and different strategies have been used for pediatric and adult patients. The current …

BACKGROUND: Synovial sarcoma (SS) is a typical soft tissue sarcoma subtype crosswise
between the pediatric and the adult age groups. Less satisfactory overall outcome has been …