ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across
cell membranes. This is clinically relevant, as tumour cells may become resistant to agents …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

ABC transporters mediate active translocation of a diverse range of molecules across all cell
membranes. They comprise two nucleotide-binding domains (NBDs) and two …

The hepatic organic anion transporting polypeptides (OATPs) influence the
pharmacokinetics of several drug classes and are involved in many clinical drug–drug …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells
known as the breast cancer resistance protein (BCRP or ABCG2) confers a strong survival …

The MRP family is comprised of nine related ABC transporters that are able to transport
structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this …

This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …