The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether
polarity loss might causally contribute to cancer has remained unclear. In Drosophila …

Metazoan physiology depends on intricate patterns of gene expression that remain poorly
known. Using transposon mutagenesis in Drosophila, we constructed a library of 7404 …

Rapid conduction in myelinated axons depends on the generation of specialized subcellular
domains to which different sets of ion channels are localized. Here, we describe the …

Myelinated fibers are organized into distinct domains that are necessary for saltatory
conduction. These domains include the nodes of Ranvier and the flanking paranodal …

LETTERS the T7 DNA polymerase ternary complex are directly applicable to KF. A similar
orientation for bound DNA was also obtained when we superposed the pol-ß carboxylate …

▪ Abstract The polarized architecture of epithelial cells and tissues is a fundamental
determinant of animal anatomy and physiology. Recent progress made in the genetic and …

Background: Secreted signaling proteins of the Wingless (Wg)/Wnt, Hedgehog and bone
morphogenetic protein (BMP)/Decapentaplegic (Dpp) families function as morphogens to …

The entire length of myelinated axons is organized into a series of polarized domains that
center around nodes of Ranvier. These domains, which are crucial for normal saltatory …

The polarized nature of epithelial cells is manifested by the nonrandom partitioning of
organelles within the cells, the concentration of intercellular junctions at one pole, and the …