Emerging phagocytosis checkpoints in cancer immunotherapy
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …
Oxidative stress and antioxidative therapy in pulmonary arterial hypertension
D Xu, YH Hu, X Gou, FY Li, XYC Yang, YM Li, F Chen - Molecules, 2022 - mdpi.com
Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase
in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently …
in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently …
Extracellular matrix dynamics in vascular remodeling
Z Ma, C Mao, Y Jia, Y Fu… - American Journal of …, 2020 - journals.physiology.org
Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …
pathophysiological alterations that are closely related to aging and vascular diseases …
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
PR Nath, D Pal-Nath, S Kaur, A Gangaplara… - …, 2022 - Taylor & Francis
ABSTRACT CD47 has established roles in the immune system for regulating macrophage
phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory …
phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory …
Thrombospondin-1 CD47 signalling: from mechanisms to medicine
Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …
[HTML][HTML] THBS1 (thrombospondin-1)
JS Isenberg, DD Roberts - Atlas of genetics and cytogenetics in …, 2020 - ncbi.nlm.nih.gov
Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is
infrequently mutated in most cancers, but its expression is positively regulated by several …
infrequently mutated in most cancers, but its expression is positively regulated by several …
Oxidative stress and antioxidant therapy in pulmonary hypertension
P Poyatos, M Gratacós, K Samuel, R Orriols… - Antioxidants, 2023 - mdpi.com
Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery
pressures and pulmonary vascular resistance. Underlying mechanisms comprise …
pressures and pulmonary vascular resistance. Underlying mechanisms comprise …
[HTML][HTML] The molecular basis for the prothrombotic state in sickle cell disease
AS Shet, MA Lizarralde-Iragorri, RP Naik - Haematologica, 2020 - ncbi.nlm.nih.gov
The genetic and molecular basis of sickle cell disease (SCD) has long been characterized
but the pathophysiological basis has not been entirely defined. How a red cell hemolytic …
but the pathophysiological basis has not been entirely defined. How a red cell hemolytic …
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes
DD Roberts, JS Isenberg - American Journal of Physiology …, 2021 - journals.physiology.org
Thrombospondin-1 (TSP1) is the prototypical member of a family of secreted proteins that
modulate cell behavior by engaging with molecules in the extracellular matrix and with …
modulate cell behavior by engaging with molecules in the extracellular matrix and with …
Specificity protein 1-mediated promotion of CXCL12 advances endothelial cell metabolism and proliferation in pulmonary hypertension
Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with
few treatment options. The underlying mechanisms of PAH appear to involve substantial …
few treatment options. The underlying mechanisms of PAH appear to involve substantial …