Chronic pain is a major socioeconomic burden globally. The most frequent origin of chronic
pain is musculoskeletal. In inflammatory musculoskeletal diseases such as rheumatoid …

Introduction The importance to assess and include the frequent comorbidities in the
personalised care management plan of patients with functional neurological disorders …

Recent translational work has shown that fibromyalgia might be an autoimmune condition
with pathogenic mechanisms mediated by a peripheral, pain-inducing action of …

Nociplastic pain is a recently distinguished type of pain, distinct from neuropathic and
nociceptive pain, and is well described in the literature. It is often mistaken for central …

Chronic pain is often present at more than one anatomical location, leading to chronic
overlapping pain conditions. Whether chronic overlapping pain conditions represent a …

Fibromyalgia (FM) is a heterogeneous condition with various mechanisms (endotype) and
manifestations (phenotypes). Many worthy endeavors have been dedicated to exploring the …

The current study used functional magnetic resonance imaging to directly compare disease-
relevant cerebral pain processing in well-characterized patient cohorts of fibromyalgia (FM …

Purpose Nociplastic pain distinguishes individuals with pain and hypersensitivity in body
regions with apparently normal tissues, without any signs of neuropathy, but with …

Chronic pain is a major healthcare issue posing a large burden on individuals and society.
Converging lines of evidence indicate that chronic pain is associated with substantial …

Objective Central sensitivity (CS) is defined as an increased responsiveness of nociceptive
neurons in the central nervous system to normal or subthreshold inputs. CS has recently …