Developing the supraparticle technology for round window-mediated drug administration into the cochlea

N Gunewardene, Y Ma, P Lam, S Wagstaff… - Journal of Controlled …, 2023 - Elsevier
The semi-permeable round window membrane (RWM) is the gateway to the cochlea.
Although the RWM is considered a minimally invasive and clinically accepted route for …

[HTML][HTML] Mucosal type of chronic suppurative otitis media and the long-term impact on hearing loss

MSA Rajput, MSA Rajput, AA Arain, SS Zaidi, A Hatem… - Cureus, 2020 - ncbi.nlm.nih.gov
Methods Patients with a diagnosis of the mucosal type of CSOM were identified from the
record of ENT, Head and Neck Surgery clinic between January 2019 and January 2020. The …

Mitigation of hearing damage after repeated blast exposures in animal model of chinchilla

S Jiang, P Welch, S Sanders, RZ Gan - … of the Association for Research in …, 2022 - Springer
High-intensity sound or blast-induced hearing impairment is a common injury for Service
members. Epidemiology studies revealed that the blast-induced hearing loss is associated …

Hearing damage induced by blast overpressure at mild TBI level in a chinchilla model

KD Smith, T Chen, RZ Gan - Military medicine, 2020 - academic.oup.com
Introduction The peripheral auditory system and various structures within the central auditory
system are vulnerable to blast injuries, and even blast overpressure is at relatively mild …

Characterization of the sheep round window membrane

S Han, H Suzuki-Kerr, M Suwantika, RS Telang… - Journal of the …, 2021 - Springer
Intratympanic injection is a clinically used approach to locally deliver therapeutic molecules
to the inner ear. Drug diffusion, at least in part, is presumed to occur through the round …

Membrane curvature and connective fiber alignment in guinea pig round window membrane

M Arriaga, DN Arteaga, D Fafalis, M Yu, X Wang… - Acta biomaterialia, 2021 - Elsevier
The round window membrane (RWM) covers an opening between the perilymph fluid-filled
inner ear space and the air-filled middle ear space. As the only non-osseous barrier …

Otojenik meningitis gelişimi ve nötrofil ektsrasellüler tuzaklarının incelenmesi

N Keskin - 2023 - search.proquest.com
Otojenik meningitis, otitisin insan ve hayvan sağlığını tehdit eden önemli
birkomplikasyonudur. Erken tanı ve tedavi, diğer pek çok patolojide olduğu gibi …

[PDF][PDF] Development of Cholesteatoma Model, Surgical Treatment, and Criteria for Disease Severity

K Smith - 2018 - core.ac.uk
There are several individuals critical to the success of this research and the future directions
we will pursue. To name a few and a footnote of their help: Dr. Rong Z. Gan for serving as …

[HTML][HTML] Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F

NK Yılmaz, H Albasan, MK Börkü… - Turkish archives of …, 2021 - ncbi.nlm.nih.gov
Objective: The purpose of this study was to investigate the morphological changes of round
window membrane (RWM) in chinchillas with Streptococcus pneumoniae (S. pneumoniae) …

[HTML][HTML] Clinical Evaluation of Hearing Loss and Tinnitus in Secretory Otitis Media

Y Gao, Q Zhang, H Luo, B Wang - Journal of Biosciences and Medicines, 2018 - scirp.org
Background: Secretory otitis media (SOM) patients usually complain about tinnitus
accompanied with a sensation of hearing loss and ear fullness. Investigation of the …