Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …

Tinnitus, a phantom perception of sound in the absence of any external sound source, is a
prevalent health condition often accompanied by psychiatric comorbidities. Recent genome …

The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on
GABA A receptors (GABA A Rs), which provides inhibitory balance to excitatory drive and …

Neurodevelopmental disorders (NDDs) are a heterogeneous class of brain diseases, with a
complex genetic basis estimated to account for up to 50% of cases. Nevertheless, genetic …

AMPA-type glutamate receptors mediate the majority of excitatory synaptic transmission in
the central nervous system. Their signaling properties and abundance at synapses are both …

Depression is the leading cause of disability and produces enormous health and economic
burdens. Current treatment approaches for depression are largely ineffective and leave …

AMPA‐type glutamate receptors (AMPARs), the key elements of fast excitatory
neurotransmission in the brain, are receptor ion channels whose core is assembled from …

Pharmacological and anatomical evidence suggests that abnormal glutamatergic
neurotransmission may be associated with the pathophysiology of depression. Compounds …

Glutamate is the major excitatory neurotransmitter in vertebrate and invertebrate nervous
systems. Proteins involved in glutamatergic neurotransmission, and chiefly glutamate …