Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases

YY Wu, HC Kuo - Journal of Biomedical Science, 2020 - Springer
Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases

L Zhang, Y Liu, Y Lu, G Wang - Biochemical pharmacology, 2022 - Elsevier
Nowadays, epigenetics is of great research value as a new gateway that can solve the
sophisticated mysteries behind neurodegenerative diseases. Epigenetic mechanisms …

Non-coding RNAs in the regulation of hippocampal neurogenesis and potential treatment targets for related disorders

Z Tan, W Li, X Cheng, Q Zhu, X Zhang - Biomolecules, 2022 - mdpi.com
Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not
encode proteins. Nonetheless, they have critical roles in a variety of cellular activities—such …

The various and shared roles of lncRNAs during development

JM Murillo‐Maldonado… - Developmental …, 2019 - Wiley Online Library
Abstract lncRNAs, genes transcribed but not translated, longer than 200 nucleotides, are
classified as a separate class of nonprotein coding genes. Since their discovery, largely from …

Potential role of lncRNA in impairing cellular properties of human neural progenitor cells following exposure to Zika virus E protein

H Arora, B Prajapati, P Seth - Experimental Neurology, 2023 - Elsevier
Zika virus (ZIKV) infection during the first trimester of the pregnancy may lead to Congenital
zika syndrome in the neonates. The viral infection hampers foetal brain development and …

Single-cell profiling of coding and noncoding genes in human dopamine neuron differentiation

F Nilsson, P Storm, E Sozzi, D Hidalgo Gil, M Birtele… - Cells, 2021 - mdpi.com
Dopaminergic (DA) neurons derived from human pluripotent stem cells (hPSCs) represent a
renewable and available source of cells useful for understanding development, developing …

The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development

B An, T Kameda, T Imamura - Essays in Biochemistry, 2021 - portlandpress.com
Increasing evidence has shown that many long non-coding RNAs (lncRNAs) are involved in
gene regulation in a variety of ways such as transcriptional, post-transcriptional and …

The functions of long non-coding RNAs in neural stem cell proliferation and differentiation

Y Zhao, H Liu, Q Zhang, Y Zhang - Cell & Bioscience, 2020 - Springer
The capacities for neural stem cells (NSCs) self-renewal with differentiation are need to be
precisely regulated for ensuring brain development and homeostasis. Recently, increasing …

Identification of lncRNAs associated with neuroblastoma in cross-sectional databases: potential biomarkers

B Prajapati, M Fatma, M Fatima, MT Khan… - Frontiers in Molecular …, 2019 - frontiersin.org
Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in
biological systems. Though the field of lncRNA has been progressing rapidly, a complete …