Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

The high frequency of RASSF1A methylation has been noted in a vast number of patients in
a broad spectrum of malignancies, suggesting that RASSF1A inactivation is associated with …

HOX genes are known as master regulator genes which give cells positional information in
embryogenesis. In this study, we compared the expression patterns of 39 HOX genes …

RASSF1A, one of the eight isoforms of the RASSF1 gene, is a tumor suppressor gene that
influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated …

The hypermethylation status of the promoter region of the breast cancer 1 (BRCA1), a well-
known tumor suppressor gene, has been extensively investigated in the last two decades as …

HOXA5 is a transcription factor and tumor suppressor that promotes differentiation of breast
epithelial cells and is frequently lost during malignant transformation. HOXA5 loss alone …

Hypermethylation at the promoter region is an important epigenetic mechanism underlying
the inactivation of tumor suppressor genes and frequently occurs as an early event in the …

Background: Methylation-mediated suppression of detoxification, DNA repair and tumor
suppressor genes has been implicated in cancer development. This study was designed to …

BACKGROUND: Aberrant methylation in the promoter of tumor-related genes is associated
closely with epigenetically mediated gene silencing. The aim of the present study was to …

BRCA1 mutations have been associated with hereditary breast cancer only. Recent studies
indicate that a subgroup of sporadic breast cancer might also be associated with reduction …