1, 3-Amino alcohols and their phenol analogs in heterocyclization reactions

VA Palchykov, AA Gaponov - Advances in Heterocyclic Chemistry, 2020 - Elsevier
The discovery of new effective catalytic methods for the synthesis of 1, 3-amino alcohols, as
well as the development of novel transformations of these compounds, has been an …

Diastereo- and Enantioselective Synthesis of Highly Functionalized Tetrahydropyridines by Recyclable Novel Bifunctional C2-Symmetric Ionic Liquid–Supported (S) …

PM Davanagere, M De, K Chanda, B Maiti - Catalysts, 2023 - mdpi.com
An efficient, novel bifunctional C 2-symmetric ionic liquid–supported (S)-proline
organocatalyst 7 was developed for a one-pot, five-component reaction involving β-keto …

Chemodivergent, one-pot, multi-component synthesis of pyrroles and tetrahydropyridines under solvent-and catalyst-free conditions using the grinding method

I Dhinakaran, V Padmini… - ACS Combinatorial …, 2016 - ACS Publications
A highly efficient, chemoselective synthesis of a library of polysubstituted pyrroles and
tetrahydropyridines has been achieved through the one-pot, multicomponent reactions of …

Diastereoselective synthesis of symmetrical and unsymmetrical tetrahydropyridines catalyzed by Bi (III) immobilized on triazine dendrimer stabilized magnetic …

B Asadi, A Landarani-Isfahani… - ACS Combinatorial …, 2017 - ACS Publications
Unsymmetrical 1, 2, 5, 6-tetrahydropyridine-3-carboxylates were obtained for the first time
from a five-component Fe3O4@ TDSN-Bi (III)-catalyzed reaction of aryl aldehydes, aryl …

[HTML][HTML] A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacetyl-1, 2, 3, 4 …

VP Andrade, M Mittersteiner, MM Lobo, CP Frizzo… - Tetrahedron …, 2018 - Elsevier
This study reports a comparison between conventional methods, ionic liquids, microwave
(MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2 …

Dramatic Effect of γ-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades

P Das, MD Delost, MH Qureshi, J Bao… - Journal of the …, 2021 - ACS Publications
We report a dramatic effect on product outcomes of the lithium ion enabled amino-Cope-like
anionic asymmetric cascade when different γ-dienolate heteroatom substituents are …

TfOH‐Catalyzed self‐Condensation of β‐Aminoketones for the Synthesis of Tetrahydropyridines

L Wu, J Chen, G Jiang, M Zhou, J Cai… - Asian Journal of …, 2024 - Wiley Online Library
A novel self‐condensation of β‐aminoketones was described. Various multisubstituted 1, 2,
3, 6‐tetrahydropyridine derivatives were synthesized in medium to good yields in the …

Synthesis of new analogs of N-substituted (benzoylamino)-1, 2, 3, 6-tetrahydropyridines

S Gedeon, LM Boyd, M Avril, M Gangapuram… - Open …, 2024 - degruyter.com
The tetrahydropyridine (THP) moiety is notably present in synthetic and natural products,
playing a cardinal role in the food, cosmetic, and pharmaceutical industries. The THP …

Diastereoselective Synthesis of 2, 6‐Disubstituted‐1, 2, 3, 6‐Tetrahydropyridines through a Palladium‐Catalyzed Intramolecular Allylic Amination

A Visseq, T Boibessot, L Nauton… - European Journal of …, 2019 - Wiley Online Library
An efficient synthesis of 2, 6‐disubstituted‐1, 2, 3, 6‐tetrahydropyridines is reported,
featuring a highly diastereoselective palladium‐catalyzed intramolecular allylic amination …

Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine

VM Lombardo, L Bernier, MZ Chen… - … Process Research & …, 2021 - ACS Publications
Despite chiral piperidines being a commonly found motif in approved drugs and drug
candidates, the synthesis of these compounds occasionally suffers from challenges of …