Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
CB Mishra, M Tiwari, CT Supuran - Medicinal Research …, 2020 - Wiley Online Library
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are widely distributed metalloenzymes in
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon …
How many carbonic anhydrase inhibition mechanisms exist?
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2016 - Taylor & Francis
Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
Advances in structure-based drug discovery of carbonic anhydrase inhibitors
CT Supuran - Expert opinion on drug discovery, 2017 - Taylor & Francis
Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum—The η-carbonic anhydrases
The genome of the protozoan parasite Plasmodium falciparum, the causative agent of the
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …
most lethal type of human malaria, contains a single gene annotated as encoding a carbonic …
Antiglaucoma carbonic anhydrase inhibitors: a patent review
Introduction: Glaucoma is one of the major causes of blindness, affecting together with age-
related macular degeneration> 70 million people worldwide. One of the therapeutic options …
related macular degeneration> 70 million people worldwide. One of the therapeutic options …
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
CT Supuran - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2013 - Taylor & Francis
Journal of Enzyme Inhibition and Medicinal Chemistry to announce that the next CA meeting
will be held in Maastricht, the Netherlands, in 2015, but a mid-term meeting will be …
will be held in Maastricht, the Netherlands, in 2015, but a mid-term meeting will be …
Acetazolamide for the treatment of idiopathic intracranial hypertension
CT Supuran - Expert Review of Neurotherapeutics, 2015 - Taylor & Francis
Idiopathic intracranial hypertension (IIH) is characterized by an increase of intracranial
pressure in the absence of neurologic tumors. The sulfonamide carbonic anhydrase (CA, EC …
pressure in the absence of neurologic tumors. The sulfonamide carbonic anhydrase (CA, EC …
Carbon-versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2018 - Taylor & Francis
A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …
Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies
(3-Tosylureido) pyridine-2-sulfonamide and 4-tosylureido-benzenesulfonamide (ts-SA) only
differ by the substitution of a CH by a nitrogen atom, but they have very different inhibitory …
differ by the substitution of a CH by a nitrogen atom, but they have very different inhibitory …