In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

ABSTRACT Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role
in various cellular pathways, including but not limited to protein trafficking, subcellular …

Estrogen receptor α (ERα) is closely associated with both hormone-dependent and hormone-
independent tumors, and it is also essential for the development of these cancers. The …

Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …

Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …

Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …

Breast cancer ranks no. 1 in women cancer worldwide, while 60–70% are estrogen receptor
alpha positive. The estrogen selective modulators, such as tamoxifen, become the effective …

The over-activation of ERα signaling is regarded as the major driver for luminal breast
cancers, which could be effective controlled via selective estrogen receptor modulators …

Background Recently genome-based studies revealed that the abnormality of Hippo
signaling is pervasive in TNBC and played important role in cancer progression. RING finger …

Breast cancer is the most commonly diagnosed malignancy in female worldwide, over 70%
of which are estrogen receptor α (ERα) positive. ERα has a crucial role in the initiation and …