The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies
G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons
Z Ruan, D Pathak, S Venkatesan Kalavai… - Brain, 2021 - academic.oup.com
Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …
Amyloid-type protein aggregation and prion-like properties of amyloids
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …
an important hallmark of protein misfolding diseases and therefore have been investigated …
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
Tau deposition patterns are associated with functional connectivity in primary tauopathies
N Franzmeier, M Brendel, L Beyer, L Slemann… - Nature …, 2022 - nature.com
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …
ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease
P Novak, B Kovacech, S Katina, R Schmidt… - Nature aging, 2021 - nature.com
Alzheimer's disease (AD) pathology is partly characterized by accumulation of aberrant
forms of tau protein. Here we report the results of ADAMANT, a 24-month double-blinded …
forms of tau protein. Here we report the results of ADAMANT, a 24-month double-blinded …
Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein
Biomolecular condensates present in cells can fundamentally affect the aggregation of
amyloidogenic proteins and play a role in the regulation of this process. While liquid-liquid …
amyloidogenic proteins and play a role in the regulation of this process. While liquid-liquid …