Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular
dystrophy (DMD), leading to terminal muscle and heart failure in patients. Somatic gene …

The ability to efficiently modify the genome using CRISPR technology has rapidly
revolutionized biology and genetics and will soon transform medicine. Duchenne muscular …

Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the
native regenerative properties of skeletal muscle and results in lifelong functional deficits …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …

Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle
progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal …

The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …