From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning
LS Li, L Yang, L Zhuang, ZY Ye, WG Zhao… - Military Medical …, 2023 - Springer
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting
individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we …
individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we …
[HTML][HTML] Cellular probing using phytoceuticals encapsulated advanced delivery systems in ameliorating lung diseases: Current trends and future prospects
JK Datsyuk, G De Rubis, KR Paudel, S Kokkinis… - International …, 2024 - Elsevier
Chronic respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD) and
asthma have posed a significant healthcare and economic cost over a prolonged duration …
asthma have posed a significant healthcare and economic cost over a prolonged duration …
Identifying ADGRG1 as a specific marker for tumor-reactive T cells in acute myeloid leukemia
Y Mei, Y Liu, W Liu, M Chen, X Liu, S Wang… - … Hematology & Oncology, 2024 - Springer
Besides chemotherapy and hematopoietic stem cell transplantation (HSCT), autologous T
cells can also serve as a new treatment approach for AML patients. However, the features of …
cells can also serve as a new treatment approach for AML patients. However, the features of …
High-dimensional mass cytometry reveals emphysema-associated changes in the pulmonary immune system
L Jia, N Li, TRM Abdelaal, N Guo… - American journal of …, 2024 - atsjournals.org
Rationale: Chronic inflammation plays an important role in alveolar tissue damage in
emphysema, but the underlying immune alterations and cellular interactions are …
emphysema, but the underlying immune alterations and cellular interactions are …
TIGIT Regulates T Cell Inflammation in Airway Inflammatory Diseases
J Ke, S Huang, Z He, S Lei, S Lin, M Duan - Inflammation, 2024 - Springer
TIGIT, a co-inhibitory receptor found on T cells and NK cells, transmits inhibitory signals
upon binding to its ligand. This interaction suppresses the activation of various signaling …
upon binding to its ligand. This interaction suppresses the activation of various signaling …
Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects
Y Qi, Y Yan, D Tang, J Han, X Zhu, M Cui… - Journal of …, 2024 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) currently ranks among the top
three causes of mortality worldwide, presenting as a prevalent and complex respiratory …
three causes of mortality worldwide, presenting as a prevalent and complex respiratory …
[HTML][HTML] Pulmonary and Systemic Immune Profiles Following Lung Volume Reduction Surgery and Allogeneic Mesenchymal Stromal Cell Treatment in Emphysema
L Jia, N Li, V van Unen, JJ Zwaginga, J Braun… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Emphysema in patients with chronic obstructive pulmonary disease (COPD) is characterized
by progressive inflammation. Preclinical studies suggest that lung volume reduction surgery …
by progressive inflammation. Preclinical studies suggest that lung volume reduction surgery …
Computational deconvolution of cell type-specific gene expression in COPD and IPF lungs reveals disease severity associations
Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary
fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes …
fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes …
Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study
Z Cao, T Wu, Y Fang, F Sun, H Ding, L Zhao… - Frontiers in …, 2024 - frontiersin.org
Objective This study employed Mendelian Randomization (MR) to investigate the causal
relationships among immune cells, COPD, and potential metabolic mediators. Methods …
relationships among immune cells, COPD, and potential metabolic mediators. Methods …