This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

The evolutionary theory of aging supports a trade-off relationship between reproduction and
aging. Aging of the male reproductive system primarily affects the testes, leading to a …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Ageing is associated with structural and functional alterations in all organs of the human
body. The ageing of gonads represents in this respect a special case, because these organs …

The ultrastructure of the progressive testicular involution with advancing age in men is
reviewed. There is no definite age at which testicular involution begins, and the onset and …

Impaired tight junction (TJ) function and autophagy and the activated p38 mitogen-activated
protein kinase (MAPK)/matrix metalloproteinase 9 (MMP9) pathway in Sertoli cells cause …

Steroidogenesis and spermatogenesis decrease in aging Brown Norway rats. We therefore
hypothesized that there must be accompanying morphological changes taking place in the …

In order to further understand age-related physiological changes and to have in depth
reference values for C57BL/6 mice, we undertook a study to assess the effects of aging on …

The observation of different types of seminiferous tubules (from tubules with normal
spermatogenesis to sclerosed tubules) in aging human testes points to the progressive …

Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a
flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve …