Global trends in HIV infection demonstrate an overall increase in HIV prevalence and
substantial declines in AIDS related deaths largely attributable to the survival benefits of …

The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …

Background Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We
implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour …

Background Antiretroviral medications that are used as prophylaxis can prevent acquisition
of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among …

Background Reproductive-age women need effective interventions to prevent the
acquisition of human immunodeficiency virus type 1 (HIV-1) infection. Methods We …

Background The incidence of human immunodeficiency virus (HIV) infection remains high
among women in sub-Saharan Africa. We evaluated the safety and efficacy of extended use …

HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …

Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women.
We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in …

Background Preexposure prophylaxis with antiretroviral agents has been shown to reduce
the transmission of human immunodeficiency virus (HIV) among men who have sex with …

Background Antiretroviral preexposure prophylaxis is a promising approach for preventing
human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations …