Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
The role of natural killer T cells in cancer—a phenotypical and functional approach
D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …
the innate and adaptive immune system. NKT cells can be subdivided into functional …
[HTML][HTML] Natural killer T cells in cancer immunotherapy
S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
The current landscape of NKT cell immunotherapy and the hills ahead
Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …
CD1: antigen presentation and T cell function
M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma
MV Dhodapkar, MD Geller, DH Chang… - The Journal of …, 2003 - rupress.org
We studied the function of antitumor T and natural killer T (NKT) cells from the blood and
tumor bed in 23 patients with premalignant gammopathy, nonprogressive myeloma, or …
tumor bed in 23 patients with premalignant gammopathy, nonprogressive myeloma, or …
Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
L Song, S Asgharzadeh, J Salo… - The Journal of …, 2009 - Am Soc Clin Investig
Tumor infiltration with Vα24-invariant NKT cells (NKTs) associates with favorable outcome in
neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d+ …
neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d+ …
Adoptive transfer of invariant NKT cells as immunotherapy for advanced melanoma: a phase I clinical trial
MA Exley, P Friedlander, N Alatrakchi, L Vriend… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with
immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients …
immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients …
[HTML][HTML] Tissue-specific roles of NKT cells in tumor immunity
M Terabe, JA Berzofsky - Frontiers in immunology, 2018 - frontiersin.org
NKT cells are an unusual population of T cells recognizing lipids presented by CD1d, a non-
classical class-I-like molecule, rather than peptides presented by conventional MHC …
classical class-I-like molecule, rather than peptides presented by conventional MHC …
The role of NKT cells in tumor immunity
M Terabe, JA Berzofsky - Advances in cancer research, 2008 - Elsevier
NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …
profound effects on the rest of the immune system despite their small numbers. They are true …