A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …

The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the
host cell surface and subsequently enters host cells through receptor-mediated endocytosis …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

Airway epithelial cells express both Ca 2+ activated TMEM16A/ANO1 and cAMP activated
CFTR anion channels. Previous work suggested a significant crosstalk of intracellular Ca 2+ …

Objective Na+/H+ exchange regulatory factor‐1 (NHERF‐1) is a class I PDZ (PSD95/Discs‐
large/ZO‐1) binding protein involved in cell‐surface expression and stabilization of …

Aging is a highly complex molecular process, affecting nearly all tissue systems in humans
and is the highest risk factor in developing neurodegenerative disorders such as Alzheimer's …

Na+-H+ exchanger regulatory factor-1 (NHERF1) is a PDZ protein that scaffolds membrane
proteins, including sodium–phosphate co-transport protein 2A (NPT2A) at the plasma …

Mechanical overloading and aging are two essential factors for osteoarthritis (OA)
development. Mitochondria have been identified as a mechano-transducer situated between …