Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

According to life history theory, increased investment in reproductive function (physiology
and behaviour) at different times throughout the life course affects the risk of many diseases …

A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …

In many populations, the a polipoprotein-ε 4 (APOE-ε 4) allele increases the risk for several
chronic diseases of aging, including dementia and cardiovascular disease; despite these …

BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

In recent years the amount of experimental data that is produced in biomedical research and
the number of papers that are being published in this field have grown rapidly. In order to …

Abstract The Industrial Revolution and the accompanying nutritional, epidemiological and
demographic transitions have profoundly changed human ecology and biology, leading to …

New applications of evolutionary biology are transforming our understanding of cancer. The
articles in this special issue provide many specific examples, such as microorganisms …

This review is aimed at readers seeking an introductory overview, teaching courses and
interested in visionary ideas. It first describes the range of topics covered by evolutionary …

Oocyte aging has a significant impact on reproductive outcomes both quantitatively and
qualitatively. However, the molecular mechanisms underlying the age-related decline in …