Focus on colon cancer
SD Markowitz, DM Dawson, J Willis, JKV Willson - Cancer cell, 2002 - cell.com
The colon and rectum comprise the final portion of the human digestive tract, commencing at
the ileocecal valve that marks the end of the small intestine, terminating at the anus, and …
the ileocecal valve that marks the end of the small intestine, terminating at the anus, and …
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
W Xia, RJ Mullin, BR Keith, LH Liu, H Ma, DW Rusnak… - Oncogene, 2002 - nature.com
Dual EGFR/erbB2 inhibition is an attractive therapeutic strategy for epithelial tumors, as
ligand-induced erbB2/EGFR heterodimerization triggers potent proliferative and survival …
ligand-induced erbB2/EGFR heterodimerization triggers potent proliferative and survival …
COX-2 and colorectal cancer
A Ferrandez, S Prescott, RW Burt - Current pharmaceutical …, 2003 - ingentaconnect.com
Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …
Characterization of HCT116 human colon cancer cells in an orthotopic model
A Rajput, ID San Martin, R Rose, A Beko… - Journal of Surgical …, 2008 - Elsevier
BACKGROUND: Colorectal cancer metastases result in a significant number of cancer
related deaths. The molecular mechanisms underlying this complex, multi-step pathway are …
related deaths. The molecular mechanisms underlying this complex, multi-step pathway are …
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apcmin mice
X Chen, J Fruehauf, JD Goldsmith, H Xu, KK Katchar… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Saccharomyces boulardii (Sb) is a probiotic yeast with anti-
inflammatory and anti-microbial activities and has been used for decades in the prevention …
inflammatory and anti-microbial activities and has been used for decades in the prevention …
Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis
I Zucchi, E Mento, VA Kuznetsov… - Proceedings of the …, 2004 - National Acad Sciences
Expression profiles of breast carcinomas are difficult to interpret when they are obtained
from tissue in toto, which may contain a large proportion of non-cancer cells. To avoid this …
from tissue in toto, which may contain a large proportion of non-cancer cells. To avoid this …
The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of …
One of the most lethal malignancies worldwide is colorectal cancer (CRC). Alterations in
various signalling pathways, including PI3K-mTOR and NF-κB, have been reported in CRC …
various signalling pathways, including PI3K-mTOR and NF-κB, have been reported in CRC …
Identification of the shared gene signature and biological mechanism between type 2 diabetes and colorectal cancer
X Liu, D Li, W Gao, W Zhao, L Jin, P Chen, H Liu… - Frontiers in …, 2023 - frontiersin.org
Background: The correlation of type 2 diabetes mellitus (T2DM) with colorectal cancer
(CRC) has garnered considerable attention in the scientific community. Despite this, the …
(CRC) has garnered considerable attention in the scientific community. Despite this, the …
Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis
Y Zhou, S Li, YP Hu, J Wang, J Hauser, AN Conway… - Cancer research, 2006 - AACR
Coexpression of the epidermal growth factor receptor (EGFR) family receptors is found in a
subset of colon cancers, which may cooperatively promote cancer cell growth and survival …
subset of colon cancers, which may cooperatively promote cancer cell growth and survival …
Blockade of epidermal growth factor-or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and …
JG Jackson, P St. Clair, MX Sliwkowski, MG Brattain - Cancer research, 2004 - AACR
Due to heterodimerization and a variety of stimulating ligands, the ErbB receptor system is
both diverse and flexible, which proves particularly advantageous to the aberrant signaling …
both diverse and flexible, which proves particularly advantageous to the aberrant signaling …