Crystal structure of the 4-hydroxybutyryl-CoA synthetase (ADP-forming) from nitrosopumilus maritimus

J Johnson, BB Tolar, B Tosun, Y Yoshikuni… - Communications …, 2024 - nature.com
Abstract The 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle from ammonia-
oxidizing Thaumarchaeota is currently considered the most energy-efficient aerobic carbon …

Structural characterization of TRAF6 N-terminal for therapeutic uses and computational studies on new derivatives

O Guven, B Sever, F Başoğlu-Ünal, A Ece, H Tateishi… - Pharmaceuticals, 2023 - mdpi.com
Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide
variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses …

Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source

M Gul, E Ayan, E Destan, JA Johnson, A Shafiei… - Scientific reports, 2023 - nature.com
High-resolution biomacromolecular structure determination is essential to better understand
protein function and dynamics. Serial crystallography is an emerging structural biology …

The crystal structure of Vibrio cholerae (6-4) photolyase reveals interactions with cofactors and a DNA-binding region

B Cakilkaya, IH Kavakli, H DeMirci - Journal of Biological Chemistry, 2023 - ASBMB
Photolyases (PLs) reverse UV-induced DNA damage using blue light as an energy source.
Of these PLs,(6-4) PLs repair (6-4)-lesioned photoproducts. We recently identified a gene …

Comparative study of high-resolution lysb29 (nε-myristoyl) des (b30) insulin structures display novel dynamic causal interrelations in monomeric-dimeric motions

E Ayan, E Destan, A Kepceoglu, HI Ciftci, A Kati… - Crystals, 2023 - mdpi.com
The treatment of insulin-dependent diabetes mellitus is characterized by artificial
supplementation of pancreatic β-cell ability to regulate sugar levels in the blood. Even …

Rapid and high resolution ambient temperature structure determination at Turkish light source

M Gul, E Ayan, E Destan, JA Johnson, A Shafiei… - bioRxiv, 2022 - biorxiv.org
High-resolution biomacromolecular structure determination is essential to better understand
protein function and dynamics. Serial crystallography is an emerging structural biology …

[PDF][PDF] Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography

M Gul, B Yuksel, H Bulut, H DeMirci - … Crystallographica Section D …, 2023 - journals.iucr.org
Candida boidinii NAD+-dependent formate dehydrogenase (CbFDH) has gained significant
attention for its potential application in the production of biofuels and various industrial …

Crystal Structure of the 4-Hydroxybutyryl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus

J Johnson, BB Tolar, B Tosun, Y Yoshikuni, CA Francis… - bioRxiv, 2023 - biorxiv.org
Abstract The 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle from ammonia-
oxidizing Thaumarchaeota is currently considered the most energy-efficient aerobic carbon …

X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers

E Ayan, M Türk, Ö Tatlı, S Bostan, E Telek, B Dingiloğlu… - bioRxiv, 2024 - biorxiv.org
Despite the crucial role of various insulin analogs in achieving satisfactory glycemic control,
a comprehensive understanding of their in-solution dynamic mechanisms still holds the …

Allosteric Residue Dynamics in Insulin: Temperature Induces Shift from Dihexamer to Hexamer Collective Motion

E Ayan, H Demirci - bioRxiv, 2025 - biorxiv.org
Structures using X-ray diffraction data collected to 2.3 A, 2.85 A, and 2.88 A resolutions have
been determined for the long-acting dihexamer insulin at three different temperatures …