The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

The advent of functional genomics has enabled the molecular biosciences to come a long
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …

Grb2-associated binder 1 (GAB1) is a scaffold protein involved in numerous interactions that
propagate signaling by growth factor and cytokine receptors. Here we explore in silico and …

We consider a model of early events in signaling by the epidermal growth factor (EGF)
receptor (EGFR). The model includes EGF, EGFR, the adapter proteins Grb2 and Shc, and …

Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …

Taking advantage of the Trp73 residue located close to the 4E-BP binding site of eIF4E, the
interaction between the 4E-BP isoform and eIF4E was investigated by the Trp fluorescence …

Interaction of proteins with charged macromolecules is involved in many processes in cells.
Firstly, there are many naturally occurred charged polymers such as DNA and RNA …

The biological function of the aspartic protease from HIV-1 has recently been related to the
conformational flexibility of its structural scaffold. Here, we use a multistep strategy to …

Ligand-activated and tyrosine-phosphorylated ErbB3 receptor binds to the SH2 domain of
the p85 subunit of phosphatidylinositol 3-kinase and initiates intracellular signaling. Here …

Classical molecular dynamics (MD) simulations based on atomic models play an
increasingly important role in a wide range of applications in physics, biology, and …