Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative
therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence …

Background The white mold fungus Sclerotinia sclerotiorum is a devastating necrotrophic
plant pathogen with a remarkably broad host range. The interaction of necrotrophs with their …

We provide evidence for CH-based nonconventional hydrogen bonds (H-bonds) for 10
Lewis antigens and two of their rhamnose analogues. We also characterize the …

The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of
Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this …

Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but
cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all …

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxins
specifically targeting eukaryotic cells through the absolute requirement for high …

Abstract Pore Forming Toxins (PFTs) represent a key mechanism for permitting the passage
of proteins and small molecules across the lipid membrane. These proteins are typically …

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial toxins that are
important virulence factors for a number of pathogenic Gram-positive bacterial species …

The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming
proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are …