The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

The accrual of cytosolic DNA leads to transcription of type I IFNs, proteolytic maturation of
the IL-1 family of cytokines, and pyroptotic cell death. Caspase-1 cleaves pro-IL1β to …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1-
infected CD4+ T cells through induction of intracellular HIV-1 protease activity, which …

NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular
danger signals and form inflammasomes. Both undergo autoproteolysis, generating N …

The danger signals that activate the related nucleotide-binding domain leucine-rich repeat
pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain …

The danger signals that activate the NLRP1 inflammasome have not been established.
Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to …

Although combined antiretroviral therapy (cART) is effective in inhibiting human
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …

Purpose: Inflammasomes are multiprotein complexes that detect danger-associated signals
and trigger an immunostimulatory form of cell death called pyroptosis. NLRP1 is an innate …

Inflammasomes are cytosolic innate immune complexes that assemble upon detection of
diverse pathogen-associated cues and play a critical role in host defense and inflammatory …