Beginning with the earliest studies of autophagy in cancer, there have been indications that
autophagy can both promote and inhibit cancer growth and progression; autophagy …

Selective autophagy represents the major quality control mechanism that ensures proper
turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER) …

Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

Gastric cancer (GC) has been recognized as the major reason for global cancer-associated
mortality. SEC62 homolog, preprotein translocation factor (SEC62) has been documented to …

Autophagy regulates the degradation of unnecessary or dysfunctional cellular components.
This catabolic process requires the formation of a double-membrane vesicle, the …

The eukaryotic cell has developed intricate machineries that monitor and maintain proteome
homeostasis in order to ensure cellular functionality. This involves the carefully coordinated …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Background and aims Sec62 is a membrane protein of the endoplasmic reticulum that
facilitates protein transport. Its role in cancer is increasingly recognised, but remains largely …

Most secreted and membrane proteins are targeted to and translocated across the
endoplasmic reticulum (ER) membrane through the Sec61 protein-conducting channel …