With the emergence of novel technologies and ground breaking concepts in BBB basic
research in the past decades, the researchers' attention on the critical role of blood brain …

Uncontrolled production of collagen I is the main feature of liver fibrosis. Following a
fibrogenic stimulus such as alcohol, hepatic stellate cells (HSC) transform into an activated …

Mood disorders are associated with hypothalamic-pituitary-adrenal axis overactivity
resulting from a decreased inhibitory feedback exerted by the hippocampus on this brain …

Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the Ig
superfamily, with various physiological roles including the induction of matrix …

Background: Cerebral edema is an important risk factor for death and poor outcome
following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still …

Ocimum gratissimum (OG) is known as a food spice and traditional herb, which has been
recommended for the treatment of various diseases. To investigate the hepatoprotective …

γ-Secretase activity has been extensively investigated due to its role in Alzheimer's disease.
Here, we studied the association of CD147, a transmembrane glycoprotein belonging to the …

Severe stroke leads to subsequent cerebral oedema. Patients with severe stroke develop
midline shift (MLS) which can be measured by transcranial duplex sonography (TCD). We …

Neuroserpin is a brain-derived natural inhibitor of tissue plasminogen activator (tPA) that
has shown neuroprotective effects in animal models of brain ischaemia. Our aim was to …

Recombinant tissue‐type plasminogen activator (rt‐PA) is presently the only
pharmacological treatment approved for thrombolysis in patients suffering from ischemic …