Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

The population of infants at risk for retinopathy of prematurity (ROP) varies by world region;
in countries with well developed neonatal intensive care services, the highest risk infants are …

Retinoblastomas result from the inactivation of the RB1 gene and the loss of Rb protein, yet
the cell type in which Rb suppresses retinoblastoma and the circuitry that underlies the need …

Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in
retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90 …

purpose. The retinoid X receptors (RXRs) are members of the family of ligand-dependent
nuclear hormone receptors. One of these genes, RXRγ, is expressed in highly restricted …

The retina remains the best studied part of the human brain. Embryologically part of the
central nervous system [1–5], but readily accessible to examination, it can be investigated …

Maintaining the strong pedagogy, abundant student-friendly examples, and engaging
conversational style of the previous editions, the sixth edition of this introductory textbook …

The scarcity of embryonic/foetal material as a resource for direct study means that there is
still limited understanding of human retina development. Here, we present an integrated …

Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of
functional RB protein. The tumors may form with few additional genomic changes and …