A perspective on polylactic acid-based polymers use for nanoparticles synthesis and applications

T Casalini, F Rossi, A Castrovinci… - … in bioengineering and …, 2019 - frontiersin.org
Polylactic acid (PLA)—based polymers are ubiquitous in the biomedical field thanks to their
combination of attractive peculiarities: biocompatibility (degradation products do not elicit …

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

JS Suk, Q Xu, N Kim, J Hanes, LM Ensign - Advanced drug delivery reviews, 2016 - Elsevier
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a
commonly used approach for improving the efficiency of drug and gene delivery to target …

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

J Liu, Q Chen, L Feng, Z Liu - Nano Today, 2018 - Elsevier
Cancer, one of major threats to the human health, possesses intricate structure and
constituents distinctive from normal organs and tissues. It has been well recognized that the …

Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking

X Duan, Y Li - Small, 2013 - Wiley Online Library
Nanoparticles have many potential applications in tumor therapy. Systemically administered
nanoparticles should remain in circulation for a long time to increase their accumulation in …

PLA micro-and nano-particles

BK Lee, Y Yun, K Park - Advanced drug delivery reviews, 2016 - Elsevier
Poly (d, l-lactic acid)(PLA) has been widely used for various biomedical applications for its
biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion …

Biodegradable polymeric nanoparticles based drug delivery systems

A Kumari, SK Yadav, SC Yadav - Colloids and surfaces B: biointerfaces, 2010 - Elsevier
Biodegradable nanoparticles have been used frequently as drug delivery vehicles due to its
grand bioavailability, better encapsulation, control release and less toxic properties. Various …

PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics

JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones… - Nano …, 2012 - ACS Publications
In this account, we varied PEGylation density on the surface of hydrogel PRINT
nanoparticles and systematically observed the effects on protein adsorption, macrophage …

Recent advances in stealth coating of nanoparticle drug delivery systems

Z Amoozgar, Y Yeo - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so‐called
PEGylation, is the most commonly used method for reducing premature clearance of NPs …

Assessment of PEG on polymeric particles surface, a key step in drug carrier translation

JM Rabanel, P Hildgen, X Banquy - Journal of controlled release, 2014 - Elsevier
Injectable drug nanocarriers have greatly benefited in their clinical development from the
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …

Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery

S Parveen, SK Sahoo - European journal of pharmacology, 2011 - Elsevier
Polymeric nanoparticles have long been sought after as carriers for systemic and targeted
drug delivery. The ability of these particles to circulate in the bloodstream for a prolonged …