Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation
SA Antar, NA Ashour, ME Marawan… - International Journal of …, 2023 - mdpi.com
Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …
[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential …
MM Hammoud, M Khattab, M Abdel-Motaal… - Journal of …, 2023 - Taylor & Francis
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
ferrocene derivative named 1-(5-(diphenylphosphaneyl) cyclopenta-1, 3-dien-1-yl) ethyl) …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Developing new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
A Abo Elmaaty, WM Eldehna, M Khattab… - International Journal of …, 2022 - mdpi.com
In this article, 34 anticoagulant drugs were screened in silico against the main protease
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …
(Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux …
A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways
Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol …
Aims Nephrotoxicity is one of the most serious health consequences of cadmium (Cd) toxic
exposure. Cd was associated with nephrotoxicity through different mechanisms including …
exposure. Cd was associated with nephrotoxicity through different mechanisms including …
Gentamicin-induced nephrotoxicity: A mechanistic approach
MA Gamaan, HS Zaky… - … International Journal of …, 2023 - aijpms.journals.ekb.eg
The kidney is more susceptible to poisoning than any other organ in the body because of the
number of poisons that are delivered to it. By 2040, it is anticipated that kidney diseases will …
number of poisons that are delivered to it. By 2040, it is anticipated that kidney diseases will …
A comprehensive overview of organ inflammatory responses: genesis, possible mechanisms, and mediators of inflammation
An immune system response known as inflammation can be carried on by a variety of things,
such as infections, damaged cells, and noxious substances. These factors may cause acute …
such as infections, damaged cells, and noxious substances. These factors may cause acute …