Myelin is critical for the proper function of the nervous system and one of the most complex
cell–cell interactions of the body. Myelination allows for the rapid conduction of action …

Charcot-Marie-Tooth (CMT) is the most prevalent category of inherited neuropathy. The most
common inheritance pattern is autosomal dominant, though there also are X-linked and …

Peripheral nerves are organ-like structures containing diverse cell types to optimize function.
This interactive assembly includes mostly axon-associated Schwann cells, but also …

Charcot-Marie-Tooth disease type 1A (CMT1A), the most common inherited demyelinating
peripheral neuropathy, is caused by PMP22 gene duplication. Overexpression of WT …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …

There is still no effective drug treatment available for Charcot-Marie-Tooth neuropathies
(CMT). Current management relies on rehabilitation therapy, surgery for skeletal deformities …

Abstract Charcot‐Marie‐Tooth (CMT) neuropathies are one of the most common
neuromuscular disorders. However, despite the identification of more than 100 causative …

Neutrophils are short-lived cells of the innate immune system and the first line of defense at
the site of an infection and tissue injury. Pattern recognition receptors on neutrophils …

Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …