Lactate, a byproduct of glycolysis, was considered as a metabolic waste until identified by
studies on the Warburg effect. Increasing evidence elucidates that lactate functions as …

Brains' high energy expenditure with preferable utilization of glucose and ketone bodies,
defines the specific features of its energy homeostasis. The extensive oxidative metabolism …

Using publicly available data sets, we compared pH in the human brain and the
cerebrospinal fluid (CSF) of postmortem control and Alzheimer's disease cases. We further …

Objective Brain glucose hypometabolism is a prominent feature of Alzheimer's disease (AD),
and in this case–control study we used Magnetic Resonance Spectroscopy (MRS) to assess …

Aerobic glycolysis and lactate production in the brain plays a key role in memory, yet the role
of this metabolism in the cognitive decline associated with Alzheimer's disease (AD) remains …

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to
lactate. Lactate has been shown to play key roles in brain energetics and memory formation …

The aim of this study was to examine brain neurometabolite concentrations in retired rugby
league players who had a history of numerous self-reported concussions. Participants were …

Beyond deficits in hippocampal-dependent episodic memory, Alzheimer's Disease (AD)
features sensory impairment in visual cognition consistent with extensive neuropathology in …

Mild cognitive impairment (MCI) is a prodromal stage in aging to possible progression to
Alzheimer's disease and related dementia (ADRD), where co-occurrence of major …

Since brain glucose hypometabolism is a feature of Alzheimer's disease (AD) progression,
lactate utilization as an energy source may become critical to maintaining central …