Modified release compositions of epalrestat or a derivative thereof and methods for using the same
I Kalofonos, J Caron, W Martin-Doyle - US Patent App. 15/431,204, 2018 - Google Patents
Currently, epalrestat is prescribed as an immediate release formulation, and therefore must
be administered three times a day. 10007] In order to provide for an effective once-a-day …
be administered three times a day. 10007] In order to provide for an effective once-a-day …
Solid forms of epalrestat
I Kalofonos, GP Stahly, W Martin-Doyle… - US Patent …, 2016 - Google Patents
The invention relates to novel crystalline salts of 5-[(1Z, 2E)-2-methyl-3-
phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal …
phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal …
Solid forms of epalrestat
I Kalofonos, GP Stahly, W Martin-Doyle… - US Patent …, 2014 - Google Patents
Related US Application Data (63) Continuation-in-part of application No.
PCT/US2009/051687, filed on Jul 24, 2009, which is a continuation-in-part of application No …
PCT/US2009/051687, filed on Jul 24, 2009, which is a continuation-in-part of application No …