Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression
Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …
MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer
S Casacuberta-Serra, Í González-Larreategui… - … and Targeted Therapy, 2024 - nature.com
RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …
being the most frequently mutated and MYC the most amplified. The cooperative interplay …
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway
J Chen, C Ding, Y Chen, W Hu, C Yu, C Peng, X Feng… - Cancer letters, 2021 - Elsevier
Lipid metabolic reprogramming plays a pivotal role in hepatocellular carcinoma (HCC)
development, but the underlying mechanisms are incompletely characterized. Long chain …
development, but the underlying mechanisms are incompletely characterized. Long chain …
Advances in lipidomics for cancer biomarkers discovery
F Perrotti, C Rosa, I Cicalini, P Sacchetta… - International journal of …, 2016 - mdpi.com
Lipids play critical functions in cellular survival, proliferation, interaction and death, since
they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell …
they are involved in chemical-energy storage, cellular signaling, cell membranes, and cell …
The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications
NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …
[PDF][PDF] Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (ie,
nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer …
nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer …
[PDF][PDF] Lipid remodeling in hepatocyte proliferation and hepatocellular carcinoma
Background and Aims Hepatocytes undergo profound metabolic rewiring when primed to
proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC) …
proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC) …
[HTML][HTML] Computer-aided drug repurposing for cancer therapy: approaches and opportunities to challenge anticancer targets
Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
JRP Knight, C Alexandrou, GL Skalka, N Vlahov… - Cancer discovery, 2021 - AACR
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant
problem for∼ 40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis …
problem for∼ 40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis …