Despite the efforts of pharmaceutical companies to develop specific kinase modulators, few
drugs targeting kinases have been completely successful in the clinic. This is primarily due …

MEK1 is an attractive target due to its role in selective extracellular‐signal‐regulated kinase
phosphorylation, which plays a pivotal role in regulating cell proliferation. Another benefit of …

Human cytomegalovirus (HCMV) expresses a variety of viral regulatory proteins that
undergo close interaction with host factors including viral-cellular multiprotein complexes …

EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very
important in tumor development as well as in angiogenesis and metastasis. In this work, 6 …

The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an
elusive goal. Herein we describe the discovery of two such clinical candidates that inhibit the …

Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …

Abstract Seventeen new pyrazolo [3, 4-d] pyrimidine derivatives have been designed,
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …

Bacteria produce biofilm not only to infect the host and spread into a new substratum but
also protect themselves against conventional antibiotics. Green silver nanoparticles …

Proto-oncogene tyrosine-protein kinase Src, also known as c-Src, belongs to the family of
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …

There has been an increasing trend in the design of novel pyrazole derivatives for desired
biological applications. For a cost-effective strategy, scientists have implemented various …