Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

[HTML][HTML] Human tuberculosis and Mycobacterium tuberculosis complex: A review on genetic diversity, pathogenesis and omics approaches in host biomarkers …

RD Kanabalan, LJ Lee, TY Lee, PP Chong… - Microbiological …, 2021 - Elsevier
Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Experimental design, population dynamics, and diversity in microbial experimental evolution

B Van den Bergh, T Swings, M Fauvart… - … and Molecular Biology …, 2018 - Am Soc Microbiol
In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial

M Tameris, H Mearns, A Penn-Nicholson… - The lancet Respiratory …, 2019 - thelancet.com
Background Infants are a key target population for new tuberculosis vaccines. We assessed
the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine …

[HTML][HTML] MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG

C Martín, D Marinova, N Aguiló, J Gonzalo-Asensio - Vaccine, 2021 - Elsevier
At its 100th birthday of its first administration to a newborn, BCG has been (and continues
being) an inspiration for the construction and development of hundreds of new TB vaccine …

In-host population dynamics of Mycobacterium tuberculosis complex during active disease

R Vargas, L Freschi, M Marin, LE Epperson, M Smith… - Elife, 2021 - elifesciences.org
Tuberculosis (TB) is a leading cause of death globally. Understanding the population
dynamics of TB's causative agent Mycobacterium tuberculosis complex (Mtbc) in-host is vital …

Campylobacter jejuni transcriptional and genetic adaptation during human infection

AA Crofts, FM Poly, CP Ewing, JM Kuroiwa… - Nature …, 2018 - nature.com
Campylobacter jejuni infections are a leading cause of bacterial food-borne diarrhoeal
illness worldwide, and Campylobacter infections in children are associated with stunted …

The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex

D Brites, S Gagneux - Strain variation in the Mycobacterium tuberculosis …, 2017 - Springer
Abstract The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of
several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this …

[PDF][PDF] The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis

RAD Castro, S Borrell, S Gagneux - FEMS microbiology reviews, 2021 - academic.oup.com
Tuberculosis (TB) has been responsible for the greatest number of human deaths due to an
infectious disease in general, and due to antimicrobial resistance (AMR) in particular. The …

Human genetic factors in tuberculosis: an update

H van Tong, TP Velavan, T Thye… - Tropical Medicine & …, 2017 - Wiley Online Library
Tuberculosis (TB) is a major threat to human health, especially in many developing
countries. Human genetic variability has been recognised to be of great relevance in host …