The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was
discovered in nematodes and found to function in most living organisms. RNAi has been …

Remarkable diversity in the domain of genome loci architecture, structure of effector
complex, array of protein composition, mechanisms of adaptation along with difference in …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Genetic screens are powerful tools for the functional annotation of genomes. In the context of
multicellular organisms, interrogation of gene function is greatly facilitated by methods that …

Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …

Abstract The Transgenic RNAi Project (TRiP), a Drosophila melanogaster functional
genomics platform at Harvard Medical School, was initiated in 2008 to generate and …

Defining the mechanisms by which animals adapt to their ecological niche is an important
problem bridging evolution, genetics, and neurobiology. We review the establishment of a …

Drosophila melanogaster is a unique, powerful genetic model organism for studying a broad
range of biological questions. Human studies that probe the genetic causes of rare and …

From flies to humans, many components of the innate immune system have been conserved
during metazoan evolution. This foundational observation has allowed us to develop …

CRISPR-Cas genome editing technologies have revolutionized the fields of functional
genetics and genome engineering, but with the recent discovery and optimization of RNA …